Signaling components as Wnt targets

Wnt signaling can promote the expression of several Wnt pathway components, indicating that feedback control is a key feature of Wnt signaling regulation.

The expression of these “Wnt pathway” genes is often more common when different cells exposed to Wnt are compared. Many other Wnt target genes are cell type specific and are less often found to be induced across different kinds of cells. Hence, expression of Wnt pathway genes such as Axin2 and Lgr5 can be a good common hallmark of active Wnt signaling.

Target Gene
Effect of Wnt signal on target gene expression
Effect of changes in target gene expression on Wnt pathway
Target gene interacts with:
Fz Down Inactivate Wnt Muller 1999
Dfz2 Down Inactivate Wnt Cadigan 1998
Dfz3 Up Activate Wnt Sato A, 1999
Fz7 up Wnt Willert 2002
Arrow/LRP Down Inactivate Wnt Wehrli et al, 2000
Dickkopf Up Inactivate LRP
Niida. 2004
Gonzalez-Sancho 2004
Chamorro 2004
Dally (HSPG) Down Wnt Baeg, 2000
Wingful/notum Up Inactivate HSPG? Giraldez et al. 2002
naked Up Inactivate Dsh Rousset et al, 2001
nemo Up Inactivate TCF Zeng , 2004
Axin2 Up Inactivate β-catenin
Yan, 2001
Lustig, 2002
Jho, 2002
b-TCRP Up Inactivate β-catenin Spiegelman 2000
TCF1 (dn) Up Inactivate TCF Roose 1999
LEF1 Down Activate β-catenin Hovanes, 2001