Publications

223 entries « 1 of 5 »

2022

Rim, EY; Clevers, H; Nusse, R

The Wnt Pathway: From Signaling Mechanisms to Synthetic Modulators. Journal Article

In: Annual review of biochemistry, 2022, ISSN: 0066-4154.

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2021

Habara, O; Logan, C Y; Kanai-Azuma, M; Nusse, R; Takase, HM

WNT signaling in pre-granulosa cells is required for ovarian folliculogenesis and female fertility. Journal Article

In: Development (Cambridge, England), vol. 148, 2021, ISSN: 0950-1991.

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Russell, JP; Lim, X; Santambrogio, A; Yianni, V; Kemkem, Y; Wang, B; Fish, M; Haston, S; Grabek, A; Hallang, S; Lodge, EJ; Patist, AL; Schedl, A; Mollard, P; Nusse, R; Andoniadou, CL

Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells. Journal Article

In: eLife, vol. 10, 2021.

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Winter, TJJ; Nusse, R

Running Against the Wnt: How Wnt/β-Catenin Suppresses Adipogenesis. Journal Article

In: Frontiers in cell and developmental biology, vol. 9, pp. 627429, 2021.

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2020

Miao, Y; Ha, A; Lau, W; Yuki, K; Santos, AJM; You, C; Geurts, MH; Puschhof, J; Pleguezuelos-Manzano, C; Peng, WC; Senlice, R; Piani, C; Buikema, JW; Gbenedio, OM; Vallon, M; Yuan, J; Haan, S; Hemrika, W; Rösch, K; Dang, LT; Baker, D; Ott, M; Depeille, P; Wu, SM; Drost, J; Nusse, R; Roose, JP; Piehler, J; Boj, SF; Janda, CY; Clevers, H; Kuo, CJ; Garcia, KC

Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In~Vivo. Journal Article

In: Cell stem cell, vol. 27, pp. 840-851.e6, 2020, ISSN: 1934-5909.

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Rim, EY; Kinney, LK; Nusse, R

β-catenin-mediated Wnt signal transduction proceeds through an endocytosis-independent mechanism. Journal Article

In: Molecular biology of the cell, vol. 31, pp. 1425-1436, 2020, ISSN: 1059-1524.

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2019

Mirabelli, CK; Nusse, R; Tuveson, DA; Williams, BO

Perspectives on the role of Wnt biology in cancer. Journal Article

In: Science signaling, vol. 12, 2019, ISSN: 1945-0877.

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Zhao, L; Jin, Y; Donahue, K; Tsui, M; Fish, M; Logan, C Y; Wang, B; Nusse, R

Tissue Repair in the Mouse Liver Following Acute Carbon Tetrachloride Depends on Injury-Induced Wnt/β-Catenin Signaling. Journal Article

In: Hepatology (Baltimore, Md.), vol. 69, pp. 2623-2635, 2019, ISSN: 0270-9139.

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Basham, KJ; Rodriguez, S; Turcu, AF; Lerario, AM; Logan, C Y; Rysztak, MR; Gomez-Sanchez, CE; Breault, DT; Koo, BK; Clevers, H; Nusse, R; Val, P; Hammer, GD

A ZNRF3-dependent Wnt/β-catenin signaling gradient is required for adrenal homeostasis. Journal Article

In: Genes & development, vol. 33, pp. 209-220, 2019, ISSN: 0890-9369.

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2018

Wan, DC; Morgan, SL; Spencley, AL; Mariano, N; Chang, EY; Shankar, G; Luo, Y; Li, TH; Huh, D; Huynh, SK; Garcia, JM; Dovey, CM; Lumb, J; Liu, L; Brown, KV; Bermudez, A; Luong, R; Zeng, H; Mascetti, VL; Pitteri, SJ; Wang, J; Tu, H; Quarta, M; Sebastiano, V; Nusse, R; Rando, TA; Carette, JE; Bazan, JF; Wang, KC

Honey bee Royalactin unlocks conserved pluripotency pathway in mammals. Journal Article

In: Nature communications, vol. 9, pp. 5078, 2018.

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Peng, WC; Logan, C Y; Fish, M; Anbarchian, T; Aguisanda, F; Álvarez-Varela, A; Wu, P; Jin, Y; Zhu, J; Li, B; Grompe, M; Wang, B; Nusse, R

Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture. Journal Article

In: Cell, vol. 175, pp. 1607-1619.e15, 2018, ISSN: 0092-8674.

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Wiese, KE; Nusse, R; Amerongen, R

Wnt signalling: conquering complexity. Journal Article

In: Development (Cambridge, England), vol. 145, 2018, ISSN: 0950-1991.

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Xing, L; Anbarchian, T; Tsai, JM; Plant, GW; Nusse, R

Wnt/β-catenin signaling regulates ependymal cell development and adult homeostasis. Journal Article

In: Proceedings of the National Academy of Sciences of the United States of America, vol. 115, pp. E5954-E5962, 2018, ISSN: 0027-8424.

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Przybyl, J; Kidzinski, L; Hastie, T; Debiec-Rychter, M; Nusse, R; Rijn, M

Gene expression profiling of low-grade endometrial stromal sarcoma indicates fusion protein-mediated activation of the Wnt signaling pathway. Journal Article

In: Gynecologic oncology, vol. 149, pp. 388-393, 2018, ISSN: 0090-8258.

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Tan, SH; Nusse, R

In vivo lineage tracing reveals Axin2-expressing, long-lived cortical thymic epithelial progenitors in the postnatal thymus. Journal Article

In: PloS one, vol. 12, pp. e0184582, 2018.

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2017

Lippert, A; Janeczek, AA; Fürstenberg, A; Ponjavic, A; Moerner, WE; Nusse, R; Helms, J A; Evans, ND; Lee, SF

Single-Molecule Imaging of Wnt3A Protein Diffusion on Living Cell Membranes. Journal Article

In: Biophysical journal, vol. 113, pp. 2762-2767, 2017, ISSN: 0006-3495.

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Brown, K; Loh, KM; Nusse, R

Live Imaging Reveals that the First Division of Differentiating Human Embryonic Stem Cells Often Yields Asymmetric Fates. Journal Article

In: Cell reports, vol. 21, pp. 301-307, 2017.

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Sigal, M; Logan, C Y; Kapalczynska, M; Mollenkopf, HJ; Berger, H; Wiedenmann, B; Nusse, R; Amieva, MR; Meyer, TF

Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis. Journal Article

In: Nature, vol. 548, pp. 451-455, 2017, ISSN: 0028-0836.

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Nusse, R; Clevers, H

Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities. Journal Article

In: Cell, vol. 169, pp. 985-999, 2017, ISSN: 0092-8674.

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2016

Loh, KM; Amerongen, R; Nusse, R

Generating Cellular Diversity and Spatial Form: Wnt Signaling and the Evolution of Multicellular Animals. Journal Article

In: Developmental cell, vol. 38, pp. 643-55, 2016, ISSN: 1534-5807.

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Lim, X; Tan, SH; Yu, KL; Lim, SB; Nusse, R

Axin2 marks quiescent hair follicle bulge stem cells that are maintained by autocrine Wnt/β-catenin signaling. Journal Article

In: Proceedings of the National Academy of Sciences of the United States of America, vol. 113, pp. E1498-505, 2016, ISSN: 0027-8424.

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Mizutani, M; Wu, JC; Nusse, R

Fibrosis of the Neonatal Mouse Heart After Cryoinjury Is Accompanied by Wnt Signaling Activation and Epicardial-to-Mesenchymal Transition. Journal Article

In: Journal of the American Heart Association, vol. 5, pp. e002457, 2016.

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Takase, HM; Nusse, R

Paracrine Wnt/β-catenin signaling mediates proliferation of undifferentiated spermatogonia in the adult mouse testis. Journal Article

In: Proceedings of the National Academy of Sciences of the United States of America, vol. 113, pp. E1489-97, 2016, ISSN: 0027-8424.

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2015

Lee, SH; Johnson, DT; Luong, R; Yu, EJ; Cunha, GR; Nusse, R; Sun, Z

Wnt/β-Catenin-Responsive Cells in Prostatic Development and Regeneration. Journal Article

In: Stem cells (Dayton, Ohio), vol. 33, pp. 3356-67, 2015, ISSN: 1066-5099.

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Wang, B; Zhao, L; Fish, M; Logan, C Y; Nusse, R

Self-renewing diploid Axin2(+) cells fuel homeostatic renewal of the liver. Journal Article

In: Nature, vol. 524, pp. 180-5, 2015, ISSN: 0028-0836.

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Guenther, CA; Wang, Z; Li, E; Tran, MC; Logan, C Y; Nusse, R; Pantalena-Filho, L; Yang, GP; Kingsley, DM

A distinct regulatory region of the Bmp5 locus activates gene expression following adult bone fracture or soft tissue injury. Journal Article

In: Bone, vol. 77, pp. 31-41, 2015, ISSN: 8756-3282.

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Sigal, M; Rothenberg, ME; Logan, C Y; Lee, JY; Honaker, RW; Cooper, RL; Passarelli, B; Camorlinga, M; Bouley, DM; Alvarez, G; Nusse, R; Torres, J; Amieva, MR

Helicobacter pylori Activates and Expands Lgr5(+) Stem Cells Through Direct Colonization of the Gastric Glands. Journal Article

In: Gastroenterology, vol. 148, pp. 1392-1404.e21, 2015, ISSN: 0016-5085.

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Nusse, R

Cell signalling: Disarming Wnt. Journal Article

In: Nature, vol. 519, pp. 163-4, 2015, ISSN: 0028-0836.

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2014

Tan, SH; Senarath-Yapa, K; Chung, MT; Longaker, MT; Wu, JY; Nusse, R

Wnts produced by Osterix-expressing osteolineage cells regulate their proliferation and differentiation. Journal Article

In: Proceedings of the National Academy of Sciences of the United States of America, vol. 111, pp. E5262-71, 2014, ISSN: 0027-8424.

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Clevers, H; Loh, KM; Nusse, R

Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control. Journal Article

In: Science (New York, N.Y.), vol. 346, pp. 1248012, 2014, ISSN: 0036-8075.

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Rinkevich, Y; Montoro, DT; Contreras-Trujillo, H; Harari-Steinberg, O; Newman, AM; Tsai, JM; Lim, X; Van-Amerongen, R; Bowman, A; Januszyk, M; Pleniceanu, O; Nusse, R; Longaker, MT; Weissman, IL; Dekel, B

In vivo clonal analysis reveals lineage-restricted progenitor characteristics in mammalian kidney development, maintenance, and regeneration. Journal Article

In: Cell reports, vol. 7, pp. 1270-83, 2014.

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Green, J; Nusse, R; Amerongen, R

The role of Ryk and Ror receptor tyrosine kinases in Wnt signal transduction. Journal Article

In: Cold Spring Harbor perspectives in biology, vol. 6, 2014.

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2013

Lim, X; Tan, SH; Koh, WL; Chau, RM; Yan, KS; Kuo, CJ; Amerongen, R; Klein, AM; Nusse, R

Interfollicular epidermal stem cells self-renew via autocrine Wnt signaling. Journal Article

In: Science (New York, N.Y.), vol. 342, pp. 1226-30, 2013, ISSN: 0036-8075.

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Sugiyama, T; Benitez, CM; Ghodasara, A; Liu, L; McLean, GW; Lee, J; Blauwkamp, TA; Nusse, R; Wright, CV; Gu, G; Kim, SK

Reconstituting pancreas development from purified progenitor cells reveals genes essential for islet differentiation. Journal Article

In: Proceedings of the National Academy of Sciences of the United States of America, vol. 110, pp. 12691-6, 2013, ISSN: 0027-8424.

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Chu, ML; Ahn, VE; Choi, HJ; Daniels, DL; Nusse, R; Weis, WI

structural Studies of Wnts and identification of an LRP6 binding site. Journal Article

In: Structure (London, England : 1993), vol. 21, pp. 1235-42, 2013, ISSN: 0969-2126.

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Bowman, AN; Amerongen, R; Palmer, TD; Nusse, R

Lineage tracing with Axin2 reveals distinct developmental and adult populations of Wnt/β-catenin-responsive neural stem cells. Journal Article

In: Proceedings of the National Academy of Sciences of the United States of America, vol. 110, pp. 7324-9, 2013, ISSN: 0027-8424.

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Green, JL; La, J; Yum, KW; Desai, P; Rodewald, LW; Zhang, X; Leblanc, M; Nusse, R; Lewis, MT; Wahl, GM

Paracrine Wnt signaling both promotes and inhibits human breast tumor growth. Journal Article

In: Proceedings of the National Academy of Sciences of the United States of America, vol. 110, pp. 6991-6, 2013, ISSN: 0027-8424.

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Habib, SJ; Chen, BC; Tsai, FC; Anastassiadis, K; Meyer, T; Betzig, E; Nusse, R

A localized Wnt signal orients asymmetric stem cell division in vitro. Journal Article

In: Science (New York, N.Y.), vol. 339, pp. 1445-8, 2013, ISSN: 0036-8075.

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Jan, TA; Chai, R; Sayyid, ZN; Amerongen, R; Xia, A; Wang, T; Sinkkonen, ST; Zeng, YA; Levin, JR; Heller, S; Nusse, R; Cheng, AG

Tympanic border cells are Wnt-responsive and can act as progenitors for postnatal mouse cochlear cells. Journal Article

In: Development (Cambridge, England), vol. 140, pp. 1196-206, 2013, ISSN: 0950-1991.

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Ardehali, R; Ali, SR; Inlay, MA; Abilez, OJ; Chen, MQ; Blauwkamp, TA; Yazawa, M; Gong, Y; Nusse, R; Drukker, M; Weissman, IL

Prospective isolation of human embryonic stem cell-derived cardiovascular progenitors that integrate into human fetal heart tissue. Journal Article

In: Proceedings of the National Academy of Sciences of the United States of America, vol. 110, pp. 3405-10, 2013, ISSN: 0027-8424.

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Lim, X; Nusse, R

Wnt signaling in skin development, homeostasis, and disease. Journal Article

In: Cold Spring Harbor perspectives in biology, vol. 5, 2013.

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Blauwkamp, TA; Nigam, S; Ardehali, R; Weissman, IL; Nusse, R

Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors. Journal Article

In: Nature communications, vol. 3, pp. 1070, 2013.

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2012

Amerongen, R; Bowman, AN; Nusse, R

Developmental stage and time dictate the fate of Wnt/β-catenin-responsive stem cells in the mammary gland. Journal Article

In: Cell stem cell, vol. 11, pp. 387-400, 2012, ISSN: 1934-5909.

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Willert, K; Nusse, R

Wnt proteins. Journal Article

In: Cold Spring Harbor perspectives in biology, vol. 4, pp. a007864, 2012.

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Amerongen, R; Fuerer, C; Mizutani, M; Nusse, R

Wnt5a can both activate and repress Wnt/β-catenin signaling during mouse embryonic development. Journal Article

In: Developmental biology, vol. 369, pp. 101-14, 2012, ISSN: 0012-1606.

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Clevers, H; Nusse, R

Wnt/β-catenin signaling and disease. Journal Article

In: Cell, vol. 149, pp. 1192-205, 2012, ISSN: 0092-8674.

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Edris, B; Espinosa, I; Mühlenberg, T; Mikels, A; Lee, CH; Steigen, SE; Zhu, S; Montgomery, KD; Lazar, AJ; Lev, D; Fletcher, JA; Beck, AH; West, RB; Nusse, R; Rijn, M

ROR2 is a novel prognostic biomarker and a potential therapeutic target in leiomyosarcoma and gastrointestinal stromal tumour. Journal Article

In: The Journal of pathology, vol. 227, pp. 223-33, 2012, ISSN: 0022-3417.

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Nusse, R; Varmus, H

Three decades of Wnts: a personal perspective on how a scientific field developed. Journal Article

In: The EMBO journal, vol. 31, pp. 2670-84, 2012, ISSN: 0261-4189.

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Chai, R; Kuo, B; Wang, T; Liaw, EJ; Xia, A; Jan, TA; Liu, Z; Taketo, MM; Oghalai, JS; Nusse, R; Zuo, J; Cheng, AG

Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea. Journal Article

In: Proceedings of the National Academy of Sciences of the United States of America, vol. 109, pp. 8167-72, 2012, ISSN: 0027-8424.

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Nusse, R

Wnt signaling. Journal Article

In: Cold Spring Harbor perspectives in biology, vol. 4, 2012.

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