Project Description

My project focuses on TBX3 (T-Box Transcription Factor 3), one of the top ten mutated genes in breast cancer. TBX3 upregulation and loss of function mutations are identified in patients, raising the question: is TBX3 a proto-oncogene or tumor suppressor? My work in the Nusse lab will define the role of TBX3 in breast cancer progression and identify TBX3 targets that can be utilized as therapeutic targets in TBX3-associated breast cancer.