Project Description

The question that I am interested in is how cells sense injury and respond to regenerate or repair damaged tissues.  Wnts are often expressed in response to tissue injury and the downstream components of the Wnt signaling pathway have been fairly well characterized.  However, the upstream mechanisms that transcriptionally activate Wnts are not well known.  My goal is to understand how injury signals are integrated at enhancers to drive Wnt expression and facilitate tissue repair.